NMR A to Z Course Prof. Gary Martin

Program:

December 2nd: NMR A to Z presentation

– Begins with simple 1D 1H and 13C spectral considerations.

– Progresses to the standard suite of 2D experiments routinely employed (by me anyway) for structure elucidation including COSY, HSQC, HMBC, and HSQC-TOCSY

– Introduces the family of ADEQUATE experiments, anisotropic NMR methods, and wraps up with i-HMBC that we developed just over a year ago that differentiated 2JCH from 3JCH HMBC correlations on the basis of sub-ppb (PPB not typo) isotope shifts.

December 4th: Florfenicol – Small Drug Molecule Lecture

– Walks students through the basic suite of 1D and 2D NMR techniques.

– Introduces the aspects of multiple halogenation (-Cl and -F) on chemical shift and using heteronuclear JCF coupling as assignment critera.

December 6th: Platensimycin – Complex Natural Product Characterization Lecture

– When platensimycin was first isolated and characterized it was necessary to utilize multiple solvent techniques due to proton overlap.

– Structural characterization using modern techniques including IDR-HSQC-TOCSY, 1,1- and 1,n-ADEQUATE, and i-HMBC will be described.

Registration

AUREMN Members – FREE

AUREMN Non-members – R$ 300,00